Poortmans PM, Collette L, Horiot JC, Van den Bogaert WF, Fourquet A, Kuten A, et al. Totally, 339 patients from 4 institutions were enrolled and analyzed retrospectively. Editors’ Picks, formerly called Papers of the Week, represent the top-rated papers published in JBC across the field of biological chemistry, as determined by our Associate Editors, Editorial Board Members and other referees. J. Biol. Patient, tumor, and treatment characteristics (n = 339), Subscription & (to A. R. S.) and National Institutes of Health Grant K99HL143277 (to P. Tumor bed boost was performed for all patients, except 1. The median duration of follow-up was 62 months (range, 17–109 months). Data from the Memorial Sloan Kettering Cancer Center showed that axillary LN recurrence was observed in 7 patients, supraclavicular LN recurrence in 2 patients, and internal mammary LN recurrence in 1 patient, among a total of 2,326 patients [9]. N Engl J Med 2015;373:317–327. All the patients underwent BCS and RT, and 88% of patients with a RS > 25 received chemotherapy. By continuing to browse this site, you agree to its use of cookies as described in our Privacy Policy. In the NSABP B-14 and B-20 trials, axillary LN recurrence was observed in 1 patient, supraclavicular LN recurrence in 3 patients, and local and regional recurrence (location not specified) in 1 patient in the BCS + RT + tamoxifen group (n = 390) [8]. Adjuvant chemotherapy guided by a 21-gene expression assay in breast cancer. Entropy provides an unexpected shield in photosynthesis, PSI relieves the pressure of membrane fusion, American Society for Biochemistry and Molecular Biology. processes to maintain homeostasis. All LRRs were observed among patients with a RS > 25, resulting in a 5-year LRR rate of 7.3% in this subgroup. In the current study, the surgical resection margin was involved in 18 patients (15 with invasive carcinoma and 3 with intraductal carcinoma), but all of them were free of LRR. Compared with historical Journal Impact data, the Metric 2019 of Journal of Biological Chemistry dropped by 4.81%. The cytosolic innate immune sensor cGAS has an unexpected STING‐independent function in compacting nuclear DNA and impeding RAD51‐mediated recombination repair. No association of positive superficial and/or deep margins with local recurrence in invasive breast cancer treated with breast-conserving surgery. Radiother Oncol 2009;90:80–85. Chem. The RS was < 11 in 55 patients, 11–25 in 241, and > 25 in 43. The Walter and Eliza Hall Institute of Medical Research (WEHI), Max Delbrück Center for Molecular Medicine. Scopus. For example, in the combined analysis of the National Surgical Adjuvant Breast and Bowel Project (NSABP) B-14 and B-20 trials, the 10-year LRR rates of the low (< 18), intermediate (18–30), and high RS (> 30) groups were 4.3%, 7.2%, and 15.8%, respectively (p < 0.0001), in patients receiving tamoxifen [8]. However, the pathogenesis of NASH is still unclear. Liangjun Zhao, Gary P. Newnam, Kavita R. Matange, Hem R. Thapa, Brett Barlow, Rebecca K. Donegan, Nguyet A. Nguyen, Emily A. R. S. is a founder of Elgia Therapeutics. Cytokine signaling is required to maintain chromatin accessibility at binding/regulatory sites for lineage‐determining transcription factors, giving it a more instructive and not just downstream role in T cell fate determination. We evaluated local, regional, and distant recurrences. Bertrand Joseph and colleagues discuss the complexities and heterogeneity of the resident macrophage cells that play key roles in CNS immune responses, suggesting function‐based categorizations and ways for further studies. Mamounas EP, Tang G, Fisher B, Paik S, Shak S, Costantino JP, et al. 2020 295: 14548. doi:10.1074/jbc.RA120.014311. PID‐2 and its newly‐identified interactors PID‐4 and PID‐5 modulate size and appearance of Z granules to establish and maintain stable heritable silencing (RNAe) by maternal piRNAs. Insights into the architecture of uromodulin filaments involved in the capture of uropathogenic bacteria, and structurally‐related vertebrate egg coat material, suggest how a widespread extracellular polymerization module can support multiple functions. Meanwhile, only a few studies are investigating whether the RS is associated with regional recurrence alone and if it can be used to select the subgroup of patients who will benefit from regional RT. Bioxbio.com includes the journal factors, ISSN, number of articles and other detailed information of over 11000 journals in different fields. Totally, 233 patients (68.7%) had T1 tumors while 105 (31.0%) had T2 tumors. Turashvili G, Chou JF, Brogi E, Morrow M, Dickler M, Norton L, et al. medication to treat this devastating disease. Article Influence: A measure of a journal's prestige based on per article citations and comparable to Impact Factor. Yoon TI, Lee JW, Lee SB, Sohn G, Kim J, Chung IY, et al. The number of citations in the data base of more than 6000 scientific journals to papers in a given journal over a two year period is divided by the number of articles published by the journal over the same time. Architecture of the centriole cartwheel-containing region revealed by cryo-electron tomography, Microbiology, Virology & Host Pathogen Interaction, Post-translational Modifications & Proteolysis, Olesia Ignatenko, Joni Nikkanen, Alexander Kononov, Nicola Zamboni, Gulayse Ince-Dunn, Anu Suomalainen. Functional studies. Clin Cancer Res 2018;24:3878–3887. permits the transition from simple steatosis to hepatocellular death; thus, activation might ameliorate multiple aspects of The current study evaluated the impact of the Oncotype DX recurrence score (RS) on the patterns of locoregional recurrence (LRR) in node-negative, hormone receptor-positive/human epidermal growth factor receptor 2-negative breast cancer. Rebecca Guth-Metzler, Anton V. Bryksin, Anton S. Petrov, Mallory Hazell, Carolyn B. Ibberson, Petar I. Penev, Robert G. Mannino, Moreover, age, type of surgery [8], T stage, and lymphovascular invasion [9] were additional prognostic factors for LRR in the multivariate analyses performed in the aforementioned studies. AMPK activity is increased by nutrient deprivation and inhibited by overnutrition, inflammation, A new tool—the “CURE” base editor—based on an APOBEC3A‐dCas13 fusion functioning with unconventional gRNAs increases efficiency and reduces off‐target substitutions in C‐to‐U RNA editing. A multipronged approach allowed engineering of an optimized A > I RNA base editor facilitating specific and efficient base editing. Enter your email address below and we will send you your username, If the address matches an existing account you will receive an email with instructions to retrieve your username, COVID-19 Notice: How we support scientific communication and options for remote access to subscribed content, This month's cover highlights the article Architecture of the centriole cartwheel-containing region revealed by cryo-electron tomography by Nikolai Klena, Maeva Le Guennec, Benjamin D. Engel, Virginie Hamel, Paul Guichard and colleagues. JBC’s at the top of the list of the most frequently chosen journals for publishing NIH-funded research. Regarding the tumor location, 119 patients had inner tumors, 170 had outer tumors, and 49 had central tumors. In the current study, regional recurrence was observed in only 3 patients among 339 patients, but these patients did not receive regional RT initially. The median age of all the patients was 47 years (range, 29–77 years). J Clin Oncol 2019;37:3340–3349. Please check your email for instructions on resetting your password. Writing - review & editing: Kim K, Jung J, Shin KH, Kim JH, Chang JH, Kim SS, Kim H, Park W, Kim YB, Chang JS. The current study evaluated the impact of the Oncotype DX recurrence score (RS) on the patterns of locoregional recurrence (LRR) in node-negative, hormone receptor-positive/human epidermal growth factor receptor 2-negative breast cancer. From J Breast Cancer. A total of 164 patients had right breast cancer and 175 had left breast cancer. The 21-gene recurrence score and locoregional recurrence in breast cancer patients. Association between the 21-gene recurrence score assay and risk of locoregional recurrence in node-negative, estrogen receptor-positive breast cancer: results from NSABP B-14 and NSABP B-20. Currently, there is no FDA-approved Report of a patient with the rare lymphatic anomaly, Kaposiform lymphangiomatosis (KLA). All patients underwent breast-conserving surgery followed by whole-breast irradiation; only 2 patients received regional nodal irradiation (RNI). The chemotherapeutic regimens were doxorubicin and cyclophosphamide in 28 patients; 5-fluorouracil, doxorubicin and cyclophosphamide in 23; docetaxel and cyclophosphamide in 6; cyclophosphamide, methotrexate, and 5-fluorouracil in 4; doxorubicin and cyclophosphamide followed by paclitaxel in 1.